Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)
Academic
About
The Leibniz Institute on Aging – Fritz Lipmann Institute in Jena is a non-university institute of the Leibniz Association dedicated to biomedical aging research. It grew out of the Institute for Molecular Biotechnology, which took part in the Human Genome Project, and adopted its aging focus and current name in 2005, describing itself as Germany's first national institute for broad biomedical aging research. Research groups study stem-cell and tissue aging, genome maintenance, proteostasis, stress tolerance, host-microbiome interactions and computational biology of aging. The institute is known for developing the short-lived turquoise killifish as a vertebrate aging model, and recent work includes killifish multi-omics resources and interpretable epigenetic clocks. Since January 2024 it has been led by Scientific Director Dario Riccardo Valenzano, with Daniele Barthel as Administrative Director, and it runs the Leibniz Graduate School on Aging.
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Publications74
- Dario Valenzano — h-index 33 source ↗
- Maria Ermolaeva — h-index 21 source ↗
- Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish (turquoise killifish genome; Reichwald et al., Cell) ↗
- Spontaneous aging-associated inflammation and genome instability in the immune system of turquoise killifish (Morabito et al., Nature Aging) ↗
- Enhancing the performance and interpretability of epigenetic clocks (TFMethyl clock; Nucleic Acids Research) ↗
- Regulation of life span by the gut microbiota in the short-lived African turquoise killifish (Smith et al./Valenzano, eLife) ↗
- Cdkn1a (p21) deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation (Choudhury et al./Rudolph, Nature Genetics) ↗
Discovery69
Trials from ClinicalTrials.gov (this org as lead sponsor), matched to aging by their condition or intervention.
Fundraising0
No public financial records found.
Education0
No public-education signals recorded.
Key outputs
- publication Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish (turquoise killifish genome; Reichwald et al., Cell) ↗ 2015
- publication Spontaneous aging-associated inflammation and genome instability in the immune system of turquoise killifish (Morabito et al., Nature Aging) ↗ 2026
- dataset or tool KIAMO – Killifish Immune Aging Multi-Omics data platform ↗ 2026
- publication Enhancing the performance and interpretability of epigenetic clocks (TFMethyl clock; Nucleic Acids Research) ↗ 2026
- dataset or tool metilene3: identifying DMRs across multiple conditions with auto-classification (Nature Communications) ↗ 2026
- publication Regulation of life span by the gut microbiota in the short-lived African turquoise killifish (Smith et al./Valenzano, eLife) ↗ 2017
- publication Cdkn1a (p21) deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation (Choudhury et al./Rudolph, Nature Genetics) ↗ 2007
- publication Integrated transcriptome and proteome analyses reveal organ-specific proteome deterioration in old rats (Ori et al., Cell Systems) ↗ 2015
- dataset or tool NFINgb - Nothobranchius furzeri Genome Browser (turquoise killifish), part of the Nothobranchius furzeri Information Network (NFIN) ↗
Investment & funding
| Date | Type | Amount | Detail | Counterparties |
|---|---|---|---|---|
| 2026-01 | grant | EUR 2M | Carl-Zeiss-Stiftung publicly disclosed Nexus programme funding of up to EUR 1.5 million over five years for the de Bakker junior research group at FLI (2026) | Carl-Zeiss-Stiftung |
Key people
Research fields
Links
Sources
- https://www.leibniz-fli.de/institute
- https://www.leibniz-fli.de/institute/history
- https://www.leibniz-fli.de/institute/organizational-structure/board-of-directors
- https://www.leibniz-fli.de/career
- https://www.leibniz-fli.de/research/research-groups
- https://www.leibniz-fli.de/news/aging-in-fast-motion-short-lived-fish-offer-new-insights-into-the-aging-immune-system
- https://www.leibniz-fli.de/news/the-black-box-of-epigenetic-clocks
- https://www.leibniz-fli.de/news/machine-learning-method-uncovers-hidden-patterns-in-dna-methylation
- https://www.leibniz-fli.de/news/carl-zeiss-foundation-funds-research-project-to-develop-new-strategies-for-preventing-neurodegenerative-diseases-2
- https://www.leibniz-gemeinschaft.de/en/institutes/list-of-leibniz-institutes/leibniz-institute-on-aging-fritz-lipmann-institute
- https://www.jenaversum.de/einrichtung/leibniz-fli/?lang=en
- https://doi.org/10.1016/j.cell.2015.10.071
- https://doi.org/10.7554/eLife.27014
- https://doi.org/10.1038/ng1937
- https://doi.org/10.1016/j.cels.2015.08.012
- https://nfingb.leibniz-fli.de/
- https://www.re3data.org/repository/r3d100010070