National Institute on Aging — Intramural Research Program
Government
About
The NIA Intramural Research Program is the in-house research arm of the US National Institute on Aging. It traces its origins to Nathan Shock's NIH gerontology unit of 1941, later the Gerontology Research Center, and runs the Baltimore Longitudinal Study of Aging, begun in 1958 and described by NIA as America's longest-running scientific study of human aging, as well as the HANDLS health-disparities cohort. NIA describes the programme as seven scientific laboratories, the Translational Gerontology Branch, the Center for Alzheimer's and Related Dementias (CARD, established 2020 with NINDS) and nine core facilities. Most laboratories are at the Biomedical Research Center on the Johns Hopkins Bayview campus in Baltimore; the Laboratory of Neurogenetics and CARD are in Bethesda. Stated priorities are neuroscience, aging biology, immunosenescence and translational gerontology, including caloric restriction, cellular senescence and mitochondrial function.
Rating breakdown
Aggregate 66/100 · rank #4 in the academic & non-profit table full ratings →
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Publications83
- Luigi Ferrucci — h-index 290 source ↗
- Rafael de Cabo — h-index 132 source ↗
- Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study (Mattison et al., Nature) ↗
- Daily fasting improves health and survival in male mice independent of diet composition and calories (Mitchell et al., Cell Metab) ↗
- Effects of intermittent fasting on health, aging, and disease (de Cabo & Mattson, New England Journal of Medicine) ↗
- Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (Ferrucci & Fabbri, Nature Reviews Cardiology) ↗
- Caloric restriction improves health and survival of rhesus monkeys (Mattison et al., Nature Communications) ↗
Discovery69
Trials from ClinicalTrials.gov (this org as lead sponsor), matched to aging by their condition or intervention.
- Baltimore Longitudinal Study of Aging (BLSA), longitudinal human aging cohort begun 1958 ↗
- Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study ↗
- CARD open-science data hub: shared long-read genomics, single-cell and iPSC resources for Alzheimer's and related dementias research ↗
Fundraising91
Grants of the organisation's listed people, name-matched via NIH RePORTER ↗.
- Rafael de Cabo: Aging Intervention Program · USD 912K · National Institute on Aging 1ZIAAG000363-18
- Luigi Ferrucci: Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling with Deuterium Oxide · USD 840K · National Institute on Aging 1ZIAAG000573-01
- Rafael de Cabo: JHU-Mayo-NIA Murine Senescence Mapping Program (JMN-MSMP) · USD 492K · National Institute on Aging 3U54AG079779-04S2
- Luigi Ferrucci: Metabolomic Signatures of Dual Cognitive and Gait Decline in relation to High Risk of Alzheimers disease in the Health ABC Study · USD 56K · National Institute on Aging 1ZIAAG000334-06
Education5
- Luigi Ferrucci ARDD speaker 2025 source ↗
Key outputs
- dataset or tool Baltimore Longitudinal Study of Aging (BLSA), longitudinal human aging cohort begun 1958 ↗ 1958
- dataset or tool Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study ↗
- publication Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study (Mattison et al., Nature) ↗ 2012
- publication Daily fasting improves health and survival in male mice independent of diet composition and calories (Mitchell et al., Cell Metab) ↗ 2019
- other NIH IRP Center for Alzheimer's and Related Dementias (CARD), led by NIA with NINDS (established 2020; Roy Blunt Center building dedicated 2022) ↗ 2020
- publication Effects of intermittent fasting on health, aging, and disease (de Cabo & Mattson, New England Journal of Medicine) ↗ 2019
- publication Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (Ferrucci & Fabbri, Nature Reviews Cardiology) ↗ 2018
- publication Caloric restriction improves health and survival of rhesus monkeys (Mattison et al., Nature Communications) ↗ 2017
- dataset or tool CARD open-science data hub: shared long-read genomics, single-cell and iPSC resources for Alzheimer's and related dementias research ↗
Investment & funding
| Date | Type | Amount | Detail | Counterparties |
|---|---|---|---|---|
| 2026 | government programme | USD 255M | National Institute on Aging publicly disclosed Intramural Research budget, FY 2026 enacted (FY 2027 Congressional Budget Justification) | US Congress (appropriations) |
| 2025 | government programme | USD 249M | National Institute on Aging publicly disclosed Intramural Research budget, FY 2025 final (FY 2027 Congressional Budget Justification) | US Congress (appropriations) |
Key people
Research fields
Links
Sources
- https://www.nia.nih.gov/research/labs/about-irp
- https://irp.nih.gov/about-us/our-programs/nia
- https://www.nia.nih.gov/research/blog/2024/07/nia-intramural-research-program-fueling-next-50-years-aging-science-discovery
- https://www.nia.nih.gov/about/history
- https://www.nia.nih.gov/about/budget/fiscal-year-2027-budget
- https://www.nia.nih.gov/about/budget/fiscal-year-2026-budget
- https://www.nia.nih.gov/research/labs/tgb
- https://www.blsa.nih.gov/about
- https://irp.nih.gov/pi/luigi-ferrucci
- https://irp.nih.gov/pi/rafael-de-cabo
- https://doi.org/10.1038/nature11432
- https://doi.org/10.1016/j.cmet.2018.08.011
- https://card.nih.gov/about-card
- https://card.nih.gov/
- https://www.nia.nih.gov/news/new-nih-alzheimers-center-accelerate-translational-research
- https://www.nia.nih.gov/research/labs/lgg
- https://www.nia.nih.gov/research/labs/lbn
- https://irp.nih.gov/pi/myriam-gorospe
- https://doi.org/10.1056/NEJMra1905136
- https://doi.org/10.1038/s41569-018-0064-2
- https://doi.org/10.1038/ncomms14063