Amy Wagers

Impact

Amy Wagers is the Forst Family Professor of Stem Cell and Regenerative Biology and Chair of Harvard's Department of Stem Cell and Regenerative Biology, and a senior investigator at the Joslin Diabetes Center. Her laboratory studies the factors and mechanisms that regulate the migration, expansion and regenerative potential of adult blood-forming and muscle-forming stem cells. Across more than 150 research and review articles, her group has identified intrinsic and extrinsic regulators of stem cell activity in injury repair, degenerative disease and malignancy, with particular attention to blood-borne mediators, cellular niches, and inflammatory and metabolic cues. For the aging field, her work on systemic regulation of stem cell function, including studies of GDF11 and myostatin and reviews of stem cell aging mechanisms and therapeutic opportunities (Nature Medicine, 2014), bears directly on circulating-factor approaches to tissue rejuvenation. Her group has also developed methods for modifying stem cell genomes in situ, including in vivo gene editing in dystrophic mouse muscle and muscle stem cells (Science, 2016). She trained with Irving Weissman at Stanford, received a 2018 NIH Pioneer Award, and is a member of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School.

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Research funding

25 NIH awards · USD 15M total NIH RePORTER ↗

• Uncovering molecular effectors of mammalian aging National Institute on Aging · 2022 · USD 1M
• Uncovering molecular effectors of mammalian aging National Institute on Aging · 2021 · USD 1M
• Uncovering molecular effectors of mammalian aging National Institute on Aging · 2020 · USD 1M
• Uncovering molecular effectors of mammalian aging National Institute on Aging · 2019 · USD 1M
• Uncovering molecular effectors of mammalian aging National Institute on Aging · 2018 · USD 1M

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