Impact
Dudley Lamming studies how nutrient-responsive signalling pathways, particularly mTOR, can be harnessed to promote metabolic health and longevity. As first author of a 2012 Science paper, he showed that the insulin resistance caused by rapamycin is mediated by loss of mTOR Complex 2 and is separable from rapamycin's effect on lifespan, a finding that informs efforts to develop safer mTOR-targeting geroprotectors. His laboratory at the University of Wisconsin–Madison found that low-protein diets improve blood sugar control and reduce adiposity in humans and mice, and identified dietary branched-chain amino acids as key regulators of these effects; it also studies how reducing branched-chain amino acid intake affects longevity and fitness, the biology of mTORC2, and whether geroprotective interventions can treat or prevent Alzheimer's disease in mouse models. He is a professor and Vice Chair for Biomedical Research in the Department of Medicine and a founding co-director of the Wisconsin Nathan Shock Center of Excellence in the Basic Biology of Aging. He is a fellow of the American Aging Association and the Gerontological Society of America and received the GSA Nathan Shock New Investigator Award.
Metrics
- h-index 61 · google scholar as of 2026-09-23 source ↗
Research output
224 works · 21,333 citations · h-index 58 OpenAlex ↗
Selected publications
- Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan ↗ 2003 · 3,801 citations
- Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity ↗ 2012 · 1,222 citations
- Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival ↗ 2007 · 950 citations
- High-fat diet enhances stemness and tumorigenicity of intestinal progenitors ↗ 2016 · 880 citations
- mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake ↗ 2012 · 777 citations
Research funding
43 NIH awards · USD 23M total NIH RePORTER ↗
- The regulation of health and longevity by branched-chain amino acids National Institute on Aging · 2023 · USD 2M
- Translational analysis of a novel intervention to promote healthy aging. National Institute on Aging · 2026 · USD 2M
- Wisconsin Nathan Shock Center National Institute on Aging · 2025 · USD 1M
- Wisconsin Nathan Shock Center National Institute on Aging · 2026 · USD 1M
- Translational analysis of a novel intervention to promote healthy aging. National Institute on Aging · 2024 · USD 660K