Impact
Riekelt Houtkooper is Professor of Translational Metabolism at Amsterdam UMC (University of Amsterdam), where his group in the Laboratory Genetic Metabolic Diseases studies mitochondrial metabolism in the contexts of inborn errors of metabolism and aging. After a PhD in Amsterdam and postdoctoral work at EPFL, he co-authored work proposing mitonuclear protein imbalance as a conserved longevity mechanism (Nature, 2013) and showing that the NAD+/sirtuin pathway modulates longevity through the mitochondrial unfolded protein response and FOXO signalling (Cell, 2013). His team uses cross-species multi-omics to study metabolic flexibility, with a particular focus on NAD+: with collaborators it has reported therapeutic effects of the NAD+ precursor nicotinamide riboside in mice, lifespan extension in C. elegans, NRH and NMNH as NAD+ boosters, and trials of nicotinamide riboside in people with compromised metabolic health. His group has also reported that NAD+ abundance associates with muscle function and healthy aging in humans (Nature Aging, 2022). He coordinates the MSCA Doctoral Network NADIS and serves on the boards of the Dutch Society for Research on Aging, the Dutch Metabolomics Center and the Emma Center for Personalized Medicine.
Metrics
- h-index 75 · google scholar as of 2026-09-23 source ↗
Research output
301 works · 24,666 citations · h-index 70 OpenAlex ↗
Selected publications
- Sirtuins as regulators of metabolism and healthspan ↗ 2012 · 2,027 citations
- Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans ↗ 2011 · 1,321 citations
- The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity ↗ 2012 · 1,263 citations
- The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling ↗ 2013 · 1,247 citations
- Mitonuclear protein imbalance as a conserved longevity mechanism ↗ 2013 · 1,080 citations