Dillin Lab (UC Berkeley)
Academic
About
The Dillin Lab at UC Berkeley studies how organisms coordinate aging across tissues. Its central question is whether each cell determines its own age or whether a hierarchy of cells sets the pace of aging for the whole body. The lab focuses on proteome maintenance — the unfolded protein responses of the endoplasmic reticulum and mitochondria and the heat shock response — which lose responsiveness with age. Its work in C. elegans showed that activating these stress responses in a few neurons or glia (in one study, just four glial cells) can signal to distant tissues and markedly extend lifespan, establishing cell-non-autonomous control of longevity. Andrew Dillin is an HHMI Investigator.
Rating breakdown
Aggregate 44/100 · rank #20 in the academic & non-profit table full ratings →
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Publications70
- Andrew Dillin — h-index 77 source ↗
- The cell-non-autonomous nature of electron transport chain-mediated longevity (Cell) ↗
- XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity (Cell) ↗
- Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans (Science) ↗
- Rates of behavior and aging specified by mitochondrial function during development (Dillin et al., Science, 2002) ↗
- Timing requirements for insulin/IGF-1 signaling in C. elegans (Dillin, Crawford & Kenyon, Science, 2002) ↗
Discovery0
No geroprotective trials, assets or deals recorded.
Fundraising87
Grants of the organisation's listed people, name-matched via NIH RePORTER ↗.
- Andrew Dillin: Extracellular Matrix Control of Mitochondrial Homeostasis and Longevity · USD 385K · National Institute on Aging 5R01AG082797-04
- Andrew Dillin: Extracellular Matrix Control of Mitochondrial Homeostasis and Longevity · USD 378K · National Institute on Aging 5R01AG082797-03
Education0
No public-education signals recorded.
Key outputs
- publication The cell-non-autonomous nature of electron transport chain-mediated longevity (Cell) ↗ 2011
- publication XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity (Cell) ↗ 2013
- publication Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans (Science) ↗ 2020
- publication Rates of behavior and aging specified by mitochondrial function during development (Dillin et al., Science, 2002) ↗ 2002
- publication Timing requirements for insulin/IGF-1 signaling in C. elegans (Dillin, Crawford & Kenyon, Science, 2002) ↗ 2002
Investment & funding
| Date | Type | Amount | Detail | Counterparties |
|---|---|---|---|---|
| 2026 | grant | USD 385K | Dillin Lab (PI Andrew Dillin) publicly disclosed (NIH RePORTER) FY2026 award for 5R01AG082797-04, 'Extracellular Matrix Control of Mitochondrial Homeostasis and Longevity' | National Institute on Aging |