Gladyshev Lab (Brigham and Women's Hospital / Harvard Medical School)
Academic
About
The Gladyshev Lab, in the Division of Genetics at Brigham and Women's Hospital and Harvard Medical School, studies the nature of ageing, rejuvenation and lifespan control by combining experimental systems, human cohorts and computational analysis. Its main lines of work are biomarkers of biological age (multi-omic and imaging- or signal-based ageing clocks, including single-cell and mouse clocks), rejuvenation biology from the rejuvenation event in early embryogenesis to partial chemical and genetic reprogramming, genetics of exceptional longevity in centenarians and long-lived species, and age-associated cellular states that drive disease. The lab also has a long record in selenium and redox biology, including definition of the mammalian selenoproteome. It releases public tools such as ClockBase, TACO, mSALT and GENtervention. For ageing research, its measurement work supplies the clocks and benchmarks used to judge whether interventions change biological age.
Rating breakdown
Aggregate 63/100 · rank #8 in the academic & non-profit table full ratings →
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Publications67
- Vadim Gladyshev — h-index 146 source ↗
- Characterization of mammalian selenoproteomes (Kryukov et al., Science, 2003) ↗
- Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging (Kerepesi et al., Science Advances, 2021) ↗
- Profiling epigenetic age in single cells (scAge; Trapp et al., Nature Aging, 2021) ↗
- Universal transcriptomic hallmarks of mammalian ageing and mortality (Tyshkovskiy et al., Nature, 2026) ↗
Discovery96
Trials from ClinicalTrials.gov (this org as lead sponsor), matched to aging by their condition or intervention.
- ClockBase: platform for biological-age computation across clocks and species (~300k GEO samples) ↗
- CausAge / DamAge / AdaptAge: causality-enriched epigenetic aging clocks (Ying et al., Nature Aging 2024) ↗
- OrganAge / organAging: open-source plasma-proteomic organ-specific aging and mortality clocks (Goeminne et al., Cell Metabolism 2024) ↗
- scAge: first single-cell DNA-methylation epigenetic clock (Trapp, Kerepesi & Gladyshev, Nature Aging 2021) ↗
- TACO: interactive app estimating transcriptomic age from gene-expression profiles ↗
- GENtervention: portal to explore gene-expression changes from lifespan-extending interventions ↗
Fundraising88
Grants of the organisation's listed people, name-matched via NIH RePORTER ↗.
- Vadim Gladyshev: Organ-Specific Biological Age and Its Applications · USD 776K · National Institute on Aging 2R01AG065403-06
- Vadim Gladyshev: Multi-omics biomarkers and molecular features of aging, longevity and Alzheimer's disease · USD 562K · National Institute on Aging 5P01AG047200-13
Education0
No public-education signals recorded.
Key outputs
- publication Characterization of mammalian selenoproteomes (Kryukov et al., Science, 2003) ↗ 2003
- publication Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging (Kerepesi et al., Science Advances, 2021) ↗ 2021
- publication Profiling epigenetic age in single cells (scAge; Trapp et al., Nature Aging, 2021) ↗ 2021
- publication Universal transcriptomic hallmarks of mammalian ageing and mortality (Tyshkovskiy et al., Nature, 2026) ↗ 2026
- dataset or tool ClockBase: platform for biological-age computation across clocks and species (~300k GEO samples) ↗
- dataset or tool CausAge / DamAge / AdaptAge: causality-enriched epigenetic aging clocks (Ying et al., Nature Aging 2024) ↗ 2024
- dataset or tool OrganAge / organAging: open-source plasma-proteomic organ-specific aging and mortality clocks (Goeminne et al., Cell Metabolism 2024) ↗ 2024
- dataset or tool scAge: first single-cell DNA-methylation epigenetic clock (Trapp, Kerepesi & Gladyshev, Nature Aging 2021) ↗ 2021
- dataset or tool TACO: interactive app estimating transcriptomic age from gene-expression profiles ↗
- dataset or tool GENtervention: portal to explore gene-expression changes from lifespan-extending interventions ↗
- dataset or tool mSALT: database of mammalian gene-expression signatures of aging and longevity ↗
Investment & funding
| Date | Type | Amount | Detail | Counterparties |
|---|---|---|---|---|
| 2026 | grant | USD 686K | Gladyshev Lab (PI Vadim N. Gladyshev) publicly disclosed (NIH RePORTER) FY2026 award for U01AG086168, 'Understanding Interorgan Communication Through Heterochronic Organ Transplantation' | National Institute on Aging (NIH) |
| 2024 | grant | USD 555K | Gladyshev Lab (PI Vadim N. Gladyshev) publicly disclosed (NIH RePORTER) FY2024 award for R01AG064223, 'Role of rare damaging mutations in aging' | National Institute on Aging (NIH) |
Key people
Research fields
Links
Sources
- https://gladyshevlab.bwh.harvard.edu/
- https://gladyshevlab.bwh.harvard.edu/team/
- https://gladyshevlab.bwh.harvard.edu/research/
- https://gladyshevlab.bwh.harvard.edu/lab-tools/
- https://gladyshevlab.bwh.harvard.edu/contact/
- https://bcmp.hms.harvard.edu/faculty-staff/vadim-gladyshev
- https://ogephd.hms.harvard.edu/people/vadim-gladyshev
- https://reporter.nih.gov/project-details/11299011
- https://reporter.nih.gov/project-details/10865065