Impact
Vadim Gladyshev is Professor of Medicine at Harvard Medical School and Director of the Center for Redox Medicine at Brigham and Women's Hospital, and an associate member of the Broad Institute. His lab combines experimental and computational approaches to study ageing, lifespan control and rejuvenation. It builds 'longevity signatures' from comparisons of long- and short-lived species, lifespan-extending interventions and cell types, and uses them to screen for new interventions. Building on human epigenetic clocks, his group developed the first mouse epigenetic ageing clocks and a single-cell clock, scAge. It reported that biological age falls during early embryogenesis around gastrulation and can be reversed by heterochronic parabiosis. He proposed the 'deleteriome' as a framework for the nature of ageing. His lab is also known for identifying the full set of 25 human selenoprotein genes and for work on selenium and redox biology. He co-authored a 2024 Nature Medicine consensus paper on validating biomarkers of ageing. He has received NIH Pioneer, Transformative and Eureka awards and is an elected member of the US National Academy of Sciences.
Metrics
- h-index 146 · google scholar as of 2026-09-23 source ↗
Research output
815 works · 57,167 citations · h-index 129 OpenAlex ↗
Selected publications
- The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions ↗ 2007 · 2,795 citations
- Characterization of Mammalian Selenoproteomes ↗ 2003 · 2,387 citations
- Selenoproteins: Molecular Pathways and Physiological Roles ↗ 2014 · 1,433 citations
- DNA methylation aging clocks: challenges and recommendations ↗ 2019 · 1,150 citations
- Reprogramming to recover youthful epigenetic information and restore vision ↗ 2020 · 872 citations
Research funding
32 NIH awards · USD 17M total NIH RePORTER ↗
- Mechanisms of lifespan control National Institute on Aging · 2018 · USD 888K
- Mechanisms of lifespan control National Institute on Aging · 2017 · USD 888K
- Mechanisms of lifespan control National Institute on Aging · 2016 · USD 888K
- Unbiased identification of interventions that extend lifespan National Institute on Aging · 2019 · USD 728K
- Unbiased identification of interventions that extend lifespan National Institute on Aging · 2022 · USD 724K