Institute for Aging Research / Institute for Geroscience, Albert Einstein College of Medicine
Academic
About
The Institute for Geroscience at Albert Einstein College of Medicine in the Bronx, formerly the Institute for Aging Research, was established in 2001. It is a membership institute that links more than 60 Einstein faculty and 40 external investigators. Research is organised into human longevity studies, mechanisms of cellular aging (autophagy, senescence, stem cell exhaustion), functional genomics and genome maintenance, integrative physiology, and gerotherapeutic interventions. Its human studies include the Longevity Genes Project, which has followed centenarians and their offspring since 1997, the LonGenity cohort (2007) and the LifeLong study (2019). Together they have enrolled more than 3,000 participants. Einstein sponsored the MILES metformin trial. Through the BIO-VITAL programme, the institute offers its aging research cores to biotech and pharmaceutical companies. Nir Barzilai directs the institute and Ana Maria Cuervo is co-director.
Rating breakdown
Aggregate 66/100 · rank #3 in the academic & non-profit table full ratings →
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Publications79
- Ana Maria Cuervo — h-index 149 source ↗
- Gil Atzmon — h-index 74 source ↗
- Sofiya Milman — h-index 29 source ↗
- Unique lipoprotein phenotype and genotype associated with exceptional longevity (CETP variant in Ashkenazi centenarians; Barzilai et al., JAMA) ↗
- Genetics of extreme human longevity to guide drug discovery for healthy ageing (Zhang et al., Nature Metabolism) ↗
- Metformin as a Tool to Target Aging (Barzilai et al., Cell Metabolism; rationale for the TAME trial) ↗
- Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function (Zhang & Cuervo, Nature Medicine) ↗
- Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians (Atzmon, Suh et al., PNAS; from the Longevity Genes Project) ↗
Discovery69
Trials from ClinicalTrials.gov (this org as lead sponsor), matched to aging by their condition or intervention.
- Longevity Genes Project – cohort of >500 healthy centenarians, near-centenarians and their children (since 1997) ↗
- Metformin in Longevity Study (MILES), sponsor Albert Einstein College of Medicine ↗
- LonGenity study – prospective cohort of adults ≥65 with and without parental exceptional longevity (since 2007) ↗
Fundraising96
Grants of the organisation's listed people, name-matched via NIH RePORTER ↗.
- Sofiya Milman: CH in Aging and Exceptional Longevity · USD 3M · National Institute on Aging 4RF1AG088659-03
- Nir Barzilai: Genetic variant-based drug discovery targeting conserved pathways of aging · USD 3M · National Institute on Aging 5U19AG056278-10
- Jan Vijg: Genetic variant-based drug discovery targeting conserved pathways of aging · USD 3M · National Institute on Aging 5U19AG056278-10
- Ana Maria Cuervo: Chaperone-Mediated Autophagy in Cardiac Fibrosis · USD 769K · National Heart Lung and Blood Institute 5R01HL174940-02
- Ana Maria Cuervo: Molecular and Cellular Mechanisms of the Lysosomal Storage Disease Cystinosis · USD 741K · National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK110162-08
- Sofiya Milman: Multi-omics approach to frailty resilience · USD 701K · National Institute on Aging 5R01AG044829-10
Education10
- Nir Barzilai public communicator
Key outputs
- dataset or tool Longevity Genes Project – cohort of >500 healthy centenarians, near-centenarians and their children (since 1997) ↗ 1997
- publication Unique lipoprotein phenotype and genotype associated with exceptional longevity (CETP variant in Ashkenazi centenarians; Barzilai et al., JAMA) ↗ 2003
- clinical trial Metformin in Longevity Study (MILES), sponsor Albert Einstein College of Medicine ↗ 2014
- dataset or tool LonGenity study – prospective cohort of adults ≥65 with and without parental exceptional longevity (since 2007) ↗ 2007
- publication Genetics of extreme human longevity to guide drug discovery for healthy ageing (Zhang et al., Nature Metabolism) ↗ 2020
- publication Metformin as a Tool to Target Aging (Barzilai et al., Cell Metabolism; rationale for the TAME trial) ↗ 2016
- publication Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function (Zhang & Cuervo, Nature Medicine) ↗ 2008
- publication Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians (Atzmon, Suh et al., PNAS; from the Longevity Genes Project) ↗ 2009
Investment & funding
| Date | Type | Amount | Detail | Counterparties |
|---|---|---|---|---|
| 2026 | other | USD 100M | Albert Einstein College of Medicine publicly disclosed nearly $100 million in aging research funding each year across the Institute for Geroscience | |
| 2024 | grant | USD 1M | NIH (NIA) publicly disclosed FY2024 award for P30 AG038072, Einstein's Nathan Shock Center of Excellence in Basic Biology of Aging (NIH RePORTER parent record) | National Institute on Aging |
| 2026 | grant | USD 3M | NIH (NIA) publicly disclosed FY2026 award for U19 AG056278, genetic variant-based drug discovery targeting conserved pathways of aging (NIH RePORTER parent record) | National Institute on Aging |
Key people
Nir BarzilaiDirector, Institute for Geroscience; Ingeborg and Ira Leon Rennert Chair in Aging Research; PI, Longevity Genes ProjectAna Maria CuervoCo-Director, Institute for Geroscience; Director, Mechanisms for Cellular Aging programmeSofiya MilmanDirector, Human Longevity StudiesJan VijgCo-director, Functional Genomics & Genome Maintenance in Aging programme; Chair, Department of GeneticsGil AtzmonAffiliated investigator (Departments of Medicine and Genetics); described on Einstein faculty page as member of the Institute for Aging Research; primary appointment now University of HaifaDerek M. HuffmanAssociate Professor of Medicine and of Molecular Pharmacology; Co-Director, Einstein Nathan Shock Center; aging-metabolism and gerotherapeutic interventions
Research fields
Links
Sources
- https://einsteinmed.edu/centers/geroscience
- https://einsteinmed.edu/centers/aging/
- https://einsteinmed.edu/centers/geroscience/research
- https://einsteinmed.edu/centers/geroscience/research/human-longevity-studies
- https://einsteinmed.edu/centers/geroscience/research/functional-genomics-genome-maintenance
- https://einsteinmed.edu/centers/geroscience/research/mechanisms-cellular-aging
- https://einsteinmed.edu/centers/geroscience/bio-vital
- https://einsteinmed.edu/faculty/484/nir-barzilai/
- https://einsteinmed.edu/faculty/8784/ana-maria-cuervo
- https://einsteinmed.edu/faculty/12865/sofiya-milman
- https://einsteinmed.edu/faculty/11318/jan-vijg
- https://einsteinmed.edu/faculty/8649/gil-atzmon
- https://doi.org/10.1007/s10522-026-10451-y
- https://reporter.nih.gov/project-details/10843919
- https://reporter.nih.gov/project-details/11399259
- https://clinicaltrials.gov/study/NCT02432287
- https://doi.org/10.1001/jama.290.15.2030
- https://doi.org/10.1038/s42255-020-0247-0
- https://einsteinmed.edu/faculty/11000/derek-m-huffman
- https://doi.org/10.1016/j.cmet.2016.05.011
- https://doi.org/10.1038/nm.1851
- https://doi.org/10.1073/pnas.0906191106