Sofiya Milman

Impact

Sofiya Milman is an endocrinologist and clinical investigator who studies the biology of human longevity through centenarians and their families, a population generally free of age-related diseases in which healthy longevity appears heritable. At Albert Einstein College of Medicine she is Professor of Medicine and of Genetics, Vice Chair for Research in the Department of Medicine, and Director of Human Longevity Studies at the Institute for Aging Research. Her team conducts translational research on genomic mechanisms that regulate endocrine and metabolic pathways protecting against diabetes, cardiovascular disease and Alzheimer's disease. A central theme is the somatotropic (growth hormone/IGF-1) axis: her work showed that lower IGF-1 levels were associated with longer survival and better cognition in people with exceptional longevity, and provided evidence against giving growth hormone to older adults to delay ageing. With Nir Barzilai and others she has published on compression of morbidity in exceptionally long-lived cohorts and on using the genetics of extreme human longevity to guide drug discovery for healthy ageing (Nature Metabolism, 2020). Her team combines computational analysis of genetic data with clinical phenotyping.

Metrics

• h-index 29 · google scholar as of 2026-09-23 source ↗
• h-index 29 · google scholar as of 2026-09-23 source ↗

Research output

127 works · 4,171 citations · h-index 29 OpenAlex ↗

Selected publications

• Undulating changes in human plasma proteome profiles across the lifespan ↗ 2019 · 1,044 citations
• Organ aging signatures in the plasma proteome track health and disease ↗ 2023 · 640 citations
• Low insulin‐like growth factor‐1 level predicts survival in humans with exceptional longevity ↗ 2014 · 231 citations
• The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research ↗ 2016 · 155 citations
• Strategies and Challenges in Clinical Trials Targeting Human Aging ↗ 2016 · 141 citations

Research funding

25 NIH awards · USD 15M total NIH RePORTER ↗

• CH in Aging and Exceptional Longevity National Institute on Aging · 2026 · USD 3M
• CH in Aging and Exceptional Longevity National Institute on Aging · 2024 · USD 1M
• CH in Aging and Exceptional Longevity National Institute on Aging · 2025 · USD 1M
• Multi-omics approach to frailty resilience National Institute on Aging · 2021 · USD 846K
• Somatotropic Signaling and Resilience to Aging and Alzheimer's Disease National Institute on Aging · 2023 · USD 829K

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Associated labs