LEV Foundation
Nonprofit
About
LEV (Longevity Escape Velocity) Foundation is a small San Francisco-based 501(c)(3) nonprofit launched in 2022 by Aubrey de Grey as his third nonprofit, with the mission to cure and prevent age-related disease. Its flagship Robust Mouse Rejuvenation (RMR) programme tests combinations of interventions started in late middle age. The first study, run at the contract research organisation Ichor Life Sciences in Syracuse, New York, treated 1,000 C57BL/6J mice from about 19 months with rapamycin, a galactose-conjugated navitoclax senolytic, AAV-mTERT telomerase gene therapy and young-donor haematopoietic stem cell transplantation, singly and in combinations; the last mouse died in February 2025. The foundation describes the lifespan result as a qualified win and plans a second study, probably in HET3 mice. It also funds tissue cryopreservation work and supports advocacy groups.
Rating breakdown
Aggregate 25/100 · rank #22 in the academic & non-profit table full ratings →
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Publications14
- Combining rejuvenation interventions in rodents: a milestone in biomedical gerontology whose time has come (Lewis & de Grey, Expert Opin Ther Targets) ↗
- The rodent aging interventions database (RAID): a data visualization tool for all studies reporting rodent lifespan extension (Peto, Floyd, Zealley & de Grey, Aging) ↗
Discovery39
Trials from ClinicalTrials.gov (this org as lead sponsor), matched to aging by their condition or intervention.
Fundraising52
Grants of the organisation's listed people, name-matched via NIH RePORTER ↗.
- Aubrey de Grey: Strategies for Engineered Negligible Senescence, 2nd Conference · USD 25K · National Institute on Aging 1R13AG026966-01
Education16
- Aubrey de Grey public communicator
- Aubrey de Grey ARDD speaker 2024 source ↗
Key outputs
- other Robust Mouse Rejuvenation Study 1 (RMR1): 1,000-mouse late-life combination-intervention lifespan study (rapamycin, senolytic, mTERT gene therapy, HSCT) ↗ 2025
- publication Combining rejuvenation interventions in rodents: a milestone in biomedical gerontology whose time has come (Lewis & de Grey, Expert Opin Ther Targets) ↗ 2024
- dataset or tool Rodent Aging Interventions Database (RAID) ↗
- other Robust Mouse Rejuvenation: Breaking the Ceiling of Longevity Research (RMR1 results summary) ↗
- publication The rodent aging interventions database (RAID): a data visualization tool for all studies reporting rodent lifespan extension (Peto, Floyd, Zealley & de Grey, Aging) ↗ 2025
- other Robust Mouse Rejuvenation Study 2 (RMR2): planned ~2,000-mouse study of 20 intervention combinations on a rapamycin + running-wheel baseline (candidate interventions include D-PUFAs, recombinant mouse serum albumin, mesenchymal stem cells, partial reprogramming, IL-11 inhibition, CASIN/Cdc42 inhibition, selective senolysis and oxytocin); strain to be C57BL/6J or HET3 ↗
Investment & funding
| Date | Type | Amount | Detail | Counterparties |
|---|---|---|---|---|
| 2025-12 | philanthropic gift | USD 2M | LEV Foundation publicly disclosed contributions and grants received in calendar year 2025 (Form 990) | |
| 2025-12 | other | USD 1M | LEV Foundation publicly disclosed total expenses for calendar year 2025 (Form 990) |
Key people
Research fields
Links
Sources
- https://www.levf.org/
- https://www.levf.org/team
- https://www.levf.org/aubreydegrey
- https://www.levf.org/projects
- https://www.levf.org/rmr
- https://www.levf.org/breaking-the-ceiling-of-longevity-research
- https://projects.propublica.org/nonprofits/organizations/932716970/202632129349301508/full
- https://projects.propublica.org/nonprofits/organizations/932716970
- https://doi.org/10.1080/14728222.2024.2330425
- https://doi.org/10.18632/aging.206228
- https://pubmed.ncbi.nlm.nih.gov/40156933/
- https://www.levf.org/projects/robust-mouse-rejuvenation-study-2