Wyss-Coray Lab (Stanford University)
Academic
About
The Wyss-Coray Lab at Stanford studies brain aging and neurodegeneration, with a focus on age-related cognitive decline and Alzheimer’s disease. It follows up earlier discoveries that circulating blood factors modulate brain structure and function and that factors from young organisms can rejuvenate old brains, and investigates the molecular basis of this systemic communication using genetic, cell-biology and proteomic approaches in model organisms and humans. The lab has developed plasma-proteome measures of organ-specific aging and openly shares aging atlases and datasets, including Tabula Muris Senis, an aging plasma proteome resource and a single-cell atlas of parabiosis. It works closely with Stanford’s Knight Initiative for Brain Resilience.
Rating breakdown
Aggregate 63/100 · rank #7 in the academic & non-profit table full ratings →
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Publications80
- Tony Wyss-Coray — h-index 119 source ↗
- The ageing systemic milieu negatively regulates neurogenesis and cognitive function (Villeda et al., Nature) ↗
- Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice (Nature Medicine) ↗
- Undulating changes in human plasma proteome profiles across the lifespan (Lehallier et al., Nature Medicine) ↗
- Organ aging signatures in the plasma proteome track health and disease (Nature) ↗
- Plasma proteomics links brain and immune system aging with healthspan and longevity (Nature Medicine) ↗
Discovery69
Trials from ClinicalTrials.gov (this org as lead sponsor), matched to aging by their condition or intervention.
- Tabula Muris Senis and Aging Plasma Proteome data portals ↗
- organage: open-source Python package computing organ-specific biological age (11 organs) from plasma proteomics (Oh, Rutledge et al., Nature 2023) ↗
- Aging Plasma Proteome: interactive Shiny app for ~2,925 plasma proteins across 4,263 individuals aged 18-95 (companion to Lehallier et al., Nature Medicine 2019) ↗
Fundraising88
Grants of the organisation's listed people, name-matched via NIH RePORTER ↗.
- Tony Wyss-Coray: The brain as a control center for other organs during aging · USD 1M · National Institute on Aging 1R01AG097491-01
- Tony Wyss-Coray: The nascent neuronal proteome of brain aging and Alzheimer's · USD 661K · National Institute on Aging 1R01AG094901-01A1
Education0
No public-education signals recorded.
Key outputs
- publication The ageing systemic milieu negatively regulates neurogenesis and cognitive function (Villeda et al., Nature) ↗ 2011
- publication Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice (Nature Medicine) ↗ 2014
- publication Undulating changes in human plasma proteome profiles across the lifespan (Lehallier et al., Nature Medicine) ↗ 2019
- publication Organ aging signatures in the plasma proteome track health and disease (Nature) ↗ 2023
- publication Plasma proteomics links brain and immune system aging with healthspan and longevity (Nature Medicine) ↗ 2025
- publication Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease (Nature) ↗ 2025
- dataset or tool Tabula Muris Senis and Aging Plasma Proteome data portals ↗
- dataset or tool organage: open-source Python package computing organ-specific biological age (11 organs) from plasma proteomics (Oh, Rutledge et al., Nature 2023) ↗ 2023
- dataset or tool Aging Plasma Proteome: interactive Shiny app for ~2,925 plasma proteins across 4,263 individuals aged 18-95 (companion to Lehallier et al., Nature Medicine 2019) ↗ 2019
Investment & funding
| Date | Type | Amount | Detail | Counterparties |
|---|---|---|---|---|
| 2025 | grant | USD 463K | Wyss-Coray Lab (PI Tony Wyss-Coray) publicly disclosed (NIH RePORTER) FY2025 award for 5R01AG072255-05, 'Molecular signature of parabiosis' | National Institute on Aging |