Tony Wyss-Coray
D.H. Chen Distinguished Professor of Neurology and Neurological Sciences; Director, Phil and Penny Knight Initiative for Brain Resilience · Stanford University
Stanford, CA, United States
Impact
Tony Wyss-Coray is the D.H. Chen Distinguished Professor of Neurology and Neurological Sciences at Stanford University and, since 2022, Director of the Phil and Penny Knight Initiative for Brain Resilience. His laboratory studies brain aging and neurodegeneration, with a focus on age-related cognitive decline and Alzheimer's disease. His group showed that circulatory blood factors can modulate brain structure and function and that factors from young organisms can rejuvenate aspects of the aged brain, including a 2014 Nature Medicine study reporting that young blood restored mental capabilities in old animals. Current work examines how the body's organ systems communicate with the brain, using genetic, cell-biological and -omics approaches in killifish, mice and humans, including plasma proteomics used to estimate the biological age of individual organs. He co-founded Alkahest in 2014 with Karoly Nikolich to develop plasma-based therapies from this research; Grifols made a $37.5 million equity investment in Alkahest in 2015. He is also a co-founder of Teal Rise, a company building aging analytics on his lab's organ-aging research. His awards include an NIH Director's Pioneer Award and an Alzheimer's Association Zenith Award.
Metrics
Research funding
31 NIH awards · USD 19M total NIH RePORTER ↗
- Microglial lipid droplets in Alzheimer's disease National Institute on Aging · 2019 · USD 4M
- Targeting CD22 to Restore Brain Homeostasis in Alzheimer's Disease National Institute on Aging · 2019 · USD 2M
- The brain as a control center for other organs during aging National Institute on Aging · 2026 · USD 1M
- A Bioorthogonal Approach to Study Mammalian Aging National Institute on Aging · 2019 · USD 785K
- A Bioorthogonal Approach to Study Mammalian Aging National Institute on Aging · 2018 · USD 785K